regenerating islet-derived protein 4 (Reg IV, REG-like protein, gastrointestinal secretory protein, REG4, GISP, RELP)
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Function
- role in inflammatory & metaplastic responses of the gastrointestinal epithelium (putative)
Structure
contains 1 C-type lectin domain
Compartment
Alternative splicing
named isoforms=3
Expression
- expressed in GI tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas, small intestine > normal colon, stomach
- expressed in mucus-secreting cells and enterocyte-like cells.
- in small intestine expressed at the basal perinuclear zone of goblet cells
Pathology
- greater expression in most colorectal tumors than in normal colon
- preferentialy expressed in mucinous tumors and in some cases neuro-endocrine tumors
- up-regulated by mucosal injury from active Crohn's disease or ulcerative colitis
- up-regulated in colorectal tumors
- up-regulated in epithelial cells at regenerating margins of peptic ulcers in the stomach & duodenum
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9BYZ8.html
- ↑ Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org/Genes/REGIVID485.html