tubulointerstitial nephritis antigen (TIN-Ag, TINAG)

Function

• mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 & alphaV-beta3

Structure

• belongs to the peptidase C1 family
• contains 1 SMB domain (somatomedin B domain)

Compartment

extracellular matrix, basement membrane

Alternative splicing

named isoforms=2

Expression

• expressed in the kidney cortex, small intestine, cornea
• initially observed in the Bowman capsule during early glomerular capillary loop formation in kidney
• in developmentally mature glomeruli, expression is higher in proximal tubular basement membrane than in distal basement membrane & Bowman capsule

Pathology

• antibodies against TINAG are found in sera of patients with tubulointerstitial nephritis

More general terms

• matrix protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/606749
• UniProt: http://www.uniprot.org/uniprot/Q9UJW2.html