thiamine transporter 2 (ThTr-2, ThTr2, solute carrier family 19 member 3, SLC19A3)

Function

• mediates high affinity thiamine uptake, via proton anti-port
• no folate transport activity

Structure

• belongs to the reduced folate carrier transporter family

Compartment

membrane

Expression

• widely expressed
• most abundant in placenta, kidney, liver

Pathology

• defects in SLC19A3 are the cause of biotin-responsive basal ganglia disease

More general terms

• solute carrier family 19 (SLC19, SLC19A)
• transmembrane 12 protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/606152
• OMIM: https://mirror.omim.org/entry/607483
• UniProt: http://www.uniprot.org/uniprot/Q9BZV2.html