folate transporter 1; FOLT; reduced folate carrier protein; RFC; intestinal folate carrier; IFC-1; placental folate transporter; solute carrier family 19 member 1 (SLC19A1, FLOT1, RFC1)

Function

• transporter for the intake of folate
• uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components
  • the folate receptor
  • the folate transporter
  • a V-type H+-pump

Structure

• heavily glycosylated
• belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family

Compartment

membrane

Expression

placenta, liver >> lung

More general terms

• transmembrane 12 protein
• folate transporter
• solute carrier family 19 (SLC19, SLC19A)
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6573
• OMIM: https://mirror.omim.org/entry/600424
• UniProt: http://www.uniprot.org/uniprot/P41440.html