EGF-like module-containing mucin-like hormone receptor-like 3 (EGF-like module-containing mucin-like receptor EMR3, EMR3)

Function

• receptor probably involved in myeloid interactions during immune & inflammatory responses
• ligand for soluble form of this receptor is present on surface of momocyte-derived macrophages & activated neutrophils

Structure

• proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit
• forms a heterodimer, consisting of large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit)
• belongs to the G-protein coupled receptor 2 family, LN-TM7 subfamily
• contains 2 EGF-like domains
• contains 1 GPS domain

Compartment

• cell membrane
• subunit alpha may be secreted

Alternative splicing

named isoforms=3

Expression

• predominantly leukocyte-restricted expression
• highest levels in neutrophils, monocytes, macrophages

More general terms

• cell surface receptor
• glycoprotein
• transmembrane 7 protein

Database

• OMIM: https://mirror.omim.org/entry/606101
• UniProt: http://www.uniprot.org/uniprot/Q9BY15.html