FRAS1-related extracellular matrix protein 1 (protein QBRICK FREM1 C9orf154)

Function

• extracellular matrix protein
• role in epidermal differentiation
• required for epidermal adhesion during embryonic development
• Calx-beta domain binds Ca+2 & undergos conformational shift

Structure

• belongs to the FRAS1 family
• contains 1 C-type lectin domain
  • contains 1 Calx-beta domain
  • contains 12 CSPG (NG2) repeats

Compartment

• secreted, extracellular matrix, basement membrane localizes at the basement membrane zone of embryonic epidermis & hair follicles

Alternative splicing

named isoforms=4

Notes

Formerly called QBRICK because it contains 12 repeats: 'Q' stands for queen & is taken from the queen being the 12th in a suit of playing card, & 'BRICK' stands for the repeating unit

More general terms

• glycoprotein
• matrix protein
• Ca+2 binding protein

Database

• OMIM: https://mirror.omim.org/entry/608944
• UniProt: http://www.uniprot.org/uniprot/Q5H8C1.html