neurotrypsin (serine protease 12, motopsin, Leydin, PRSS12)

Function

• role in neuronal plasticity
• proteolytic action may subserve structural reorganizations associated with learning & memory operations

Structure

• belongs to the peptidase S1 family
• contains 1 kringle domain
  • contains 1 peptidase S1 domain
  • contains 4 SRCR domains

Compartment

secreted

Expression

expressed in brain & Leydig cells of testis

Pathology

• defects in PRSS12 are a cause of autosomal recessive nonsyndromic mental retardation

More general terms

• serine protease
• secreted protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/249500
• OMIM: https://mirror.omim.org/entry/606709
• UniProt: http://www.uniprot.org/uniprot/P56730.html