spondin-1 (F-spondin, vascular smooth muscle cell growth-promoting factor, SPON1, KIAA0762, VSGP)

Function

• cell adhesion protein
• promotes attachment of spinal cord & sensory neuron cells
• promotes outgrowth of neurites in vitro
• growth & guidance of axons in both the spinal cord and the peripheral nervous system (putative)
• major factor for vascular smooth muscle cell
• binds to the central extracellular domain of APP
• inhibits beta-secretase cleavage of APP

Compartment

secreted

Expression

• expressed in lung > brain, heart, kidney, liver, testis > pancreas, skeletal muscle, ovary
• not expressed in spleen

More general terms

• spondin
• cell adhesion protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/604989
• UniProt: http://www.uniprot.org/uniprot/Q9HCB6.html