synaptic vesicle glycoprotein 2B (SV2B, KIAA0735)

Function

• control of regulated secretion in neural & endocrine cells
• interacts with SYT1 (Ca+2-dependent)
• forms a complex with SYT1, syntaxin-1 & SNAP25
• N-glycosylated

Compartment

• cytoplasmic vesicle, secretory vesicle, synaptic vesicle, synaptic vesicle membrane, acrosome
• associated with synaptic-like microvesicles but NOT with insulin-containing vesicles in insulin-secreting cells of the pancreas
• localizes to microvesicles in the pinealocytes
• localizes to the acrosome in spermatids

More general terms

• transmembrane 12 protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/185861
• UniProt: http://www.uniprot.org/uniprot/Q7L1I2.html