interleukin-18-binding protein; IL-18BP; Tadekinig-alfa (IL18BP)

Function

• isoform A binds to IL-18 & inhibits its activity
• inhibitor of the early TH1 cytokine response

Structure

• N-glycosylated & O-glycosylated with core 1-like & core 2-like glycan
• O-glycan heterogeneity at Ser-53: hexhexNAc (major) & hex2hexNAc2 (minor).
• N-glycan heterogeneity at Asn-103: hex5hexNAc4 (minor), dhex1hex5hexNAc4 (major) & hex6hexNAc5 (minor)
• N-glycan at Asn-147: dhex1hex5hexNAc4
• contains 1 Ig-like C2-type domain

Compartment

secreted

Alternative splicing

named isoforms=3; A, B, D

Expression

strongly expressed in heart, lung, placenta, spleen

More general terms

• secreted protein
• glycoprotein

Additional terms

• interleukin-18; IL-18; Iboctadekin; interferon gamma-inducing factor; IFN-gamma-inducing factor; interleukin-1 gamma; IL-1 gamma (IL18, IGIF, IL1F4)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10068
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10068
• OMIM: https://mirror.omim.org/entry/604113
• UniProt: http://www.uniprot.org/uniprot/O95998.html