solute carrier family 12 member 7; electroneutral K+-chloride cotransporter 4; K-Cl cotransporter 4 (SLC12A7, KCC4)

Function

• mediates electroneutral K+-chloride cotransport when activated by cell swelling
• may mediate K+ uptake into Deiters' cells in the cochlea & contribute to K+ recycling in the inner ear
• important for the survival of cochlear outer & inner hair cells & the maintenance of the organ of Corti
• may be required for basolateral Cl- extrusion in the kidney & contribute to renal acidification
• activated by N-ethylmaleimide (NEM)
• inhibited by furosemide, DIDS & bumetanide; inhibition is much stronger in the presence of 50 mM K+
• inhibited by DIOA
• homomultimer & heteromultimer with other K-Cl cotransporters (putative)

Structure

• belongs to the SLC12A transporter family

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• detected in muscle, brain, lung, heart & kidney

More general terms

• transmembrane 12 protein
• glycoprotein
• solute carrier family 12 (SLC12, SLC12A)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10723
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10723
• OMIM: https://mirror.omim.org/entry/604879
• UniProt: http://www.uniprot.org/uniprot/Q9Y666.html