solute carrier family 6 member 5; Na+- & chloride-dependent glycine transporter 2; GlyT-2; GlyT2 (SLC6A5, GLYT2, NET1)

Function

• terminates the action of glycine by its high affinity Na+-dependent reuptake into presynaptic terminals
• may be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses

Structure

• belongs to the Na+:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A5 subfamily

Compartment

membrane

Expression

• expressed in medulla oblongata, & to a lesser extent in spinal cord & cerebellum

Pathology

• defects in SLC6A5 are a cause of startle disease

More general terms

• solute carrier family 6
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9152
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9152
• OMIM: https://mirror.omim.org/entry/149400
• OMIM: https://mirror.omim.org/entry/604159
• UniProt: http://www.uniprot.org/uniprot/Q9Y345.html