solute carrier family 2 member 9 (facilitated glucose transporter); glucose transporter type 9; GLUT-9 (SLC2A9, GLUT9)

Function

• transport of urate & fructose
• may have a role in urate reabsorption by proximal tubules
• also transports glucose at low rate

Structure

• belongs to the major facilitator superfamily, sugar transporter (TC 2.A.1.1) family, glucose transporter subfamily

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• highest expression in basolateral membranes of proximal renal tubular cells, liver & placenta
• also detected in lung, blood leukocytes, heart, skeletal muscle & chondrocytes from articular cartilage
• isoform 2 is only detected in the apical membranes of polarized renal tubular cells & placenta
• isoform 1 & isoform 2 are detected in kidney membrane (at protein level)

Polymorphism

• genetic variations in SLC2A9 influence the variance in serum uric acid concentrations

More general terms

• glucose transporter
• glycoprotein
• solute carrier family 2 (SLC2, SLC2A)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56606
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56606
• OMIM: https://mirror.omim.org/entry/606142
• OMIM: https://mirror.omim.org/entry/612076
• UniProt: http://www.uniprot.org/uniprot/Q9NRM0.html