solute carrier family 12 member 5; electroneutral K+-chloride cotransporter 2; K-Cl cotransporter 2; hKCC2; neuronal K-Cl cotransporter (SLC12A5, KCC2, KIAA1176)

Function

• mediates electroneutral K+-chloride cotransport in mature neurons
• transport occurs under isotonic conditions, but is activated 20-fold by cell swelling
• important for Cl- homeostasis in neurons
• homomultimer & heteromultimer with other K-Cl cotransporters
• interacts with AP2A1 (putative)

Structure

belongs to the SLC12A transporter family

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• brain specific, detected in neurons

Notes

• inhibited by furosemide & bumetanide

More general terms

• transmembrane 12 protein
• glycoprotein
• solute carrier family 12 (SLC12, SLC12A)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57468
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57468
• OMIM: https://mirror.omim.org/entry/606726
• UniProt: http://www.uniprot.org/uniprot/Q9H2X9.html