solute carrier family 1 member 5; neutral amino acid transporter B(0); ATB(0); Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Na+-dependent neutral amino acid transporter type 2 (SLC1A5, ASCT2, M7V1, RDR RDRC)

Function

• broad substrate specificity
• a preference for zwitterionic amino acids
• Na+-dependent
• accepts as substrates all neutral amino acids, including glutamine, asparagine, branched-chain amino acids & aromatic amino acids
• excludes methylated amino acids, anionic amino acids, & cationic amino acids
• cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus & type D simian retroviruses

Structure

• belongs to the Na+:dicarboxylate (SDF) symporter (TC 2.A.23) family, SLC1A5 subfamily

Compartment

• membrane
• melanosome (stage 1-4)

Alternative initiation

• named isoforms=1
• a number of isoforms are produced by alternative initiation
• isoforms start at multiple alternative CUG & GUG codons

Expression

• expresse in placenta, lung, skeletal muscle, kidney, pancreas, & intestine

More general terms

• transmembrane 10 protein
• glycoprotein
• solute carrier family 1 (SLC1 SLC1A)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6510
• OMIM: https://mirror.omim.org/entry/109190
• UniProt: http://www.uniprot.org/uniprot/Q15758.html