K+ voltage-gated channel subfamily E member 4; minK-related peptide 3; minimum K+ channel-related peptide 3; K+ channel subunit beta MiRP3 (KCNE4)

Function

• ancillary protein that assembles as a beta subunit with a voltage-gated K+ channel complex of pore-forming alpha subunits
• modulates the gating kinetics & enhances stability of the channel complex
• may associate with KCNQ1/KVLTQ1 & inhibit K+ current

Structure

belongs to the K+ channel KCNE family

Compartment

• membrane; single-pass type 1 membrane protein

Expression

• predominantly expressed in embryo & adult uterus
• low expression found in kidney, small intestine, lung & heart

More general terms

• glycoprotein
• K+ channel subfamily E

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23704
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23704
• OMIM: https://mirror.omim.org/entry/607775
• UniProt: http://www.uniprot.org/uniprot/Q8WWG9.html