K+ voltage-gated channel subfamily C member 4; KSHIIIC; voltage-gated K+ channel subunit Kv3.4 (KCNC4)

Function

• mediates voltage-dependent K+ ion permeability of excitable membranes
• opens & closes in response to the voltage difference across the membrane
• forms a K+-selective channel through which K+ may pass in accordance with the electrochemical gradient
• phosphorylation of Ser in the inactivation gate inhibits rapid channel closure
• homotetramer (probable)
• heterotetramer of K+ channel proteins (putative)

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• the tail may be important in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
• belongs to the K+ channel family, C (Shaw) (TC 1.A.1.2) subfamily, Kv3.4/KCNC4 sub-subfamily

Compartment

membrane

Alternative splicing

named isoforms=2

More general terms

• transmembrane 6 protein
• K+ channel subfamily C
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3749
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3749
• OMIM: https://mirror.omim.org/entry/176265
• UniProt: http://www.uniprot.org/uniprot/Q03721.html