K+ voltage-gated channel subfamily C member 3; KSHIIID; voltage-gated K+ channel subunit Kv3.3 (KCNC3)

Function

• mediates voltage-dependent K+ permeability of excitable membranes
• opens & closes in response to the voltage difference across the membrane
• forms a K+-selective channel through which K+ may pass in accordance with the electrochemical gradient
• heterotetramer of K+ channel proteins

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• the tail may be important in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
• belongs to the K+ channel family, C (Shaw) (TC 1.A.1.2) subfamily, Kv3.3/KCNC3 sub-subfamily

Compartment

membrane

Pathology

• defects in KCNC3 are the cause of spinocerebellar ataxia type 13

More general terms

• transmembrane 6 protein
• K+ channel subfamily C
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3748
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3748
• OMIM: https://mirror.omim.org/entry/176264
• OMIM: https://mirror.omim.org/entry/605259
• UniProt: http://www.uniprot.org/uniprot/Q14003.html