K+ voltage-gated channel subfamily B member 2; voltage-gated K+ channel subunit Kv2.2 (KCNB2)

Function

• mediates voltage-dependent K+ permeability of excitable membranes
• channels open or close in response to the voltage difference across the membrane, letting K+ pass in accordance with the electrochemical gradient
• phosphorylated (putative)
• heteromultimer with KCNS1, KCNS2 & KCNS3

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• the tail may be important in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
• belongs to the K+ channel family, B (Shab) (TC 1.A.1.2) subfamily, Kv2.2/KCNB2 sub-subfamily

Compartment

membrane

More general terms

• transmembrane 6 protein
• K+ channel subfamily B
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9312
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9312
• OMIM: https://mirror.omim.org/entry/607738
• UniProt: http://www.uniprot.org/uniprot/Q92953.html