K+ voltage-gated channel subfamily S member 1; delayed-rectifier K+ channel alpha subunit 1; voltage-gated K+ channel subunit Kv9.1 (KCNS1)

Function

• K+ channel subunit
• modulates channel activity & reduces the ion flow (putative)
• heteromultimer with KCNB1 & with KCNB2
• does not form homomultimers
• might also bind to other channel proteins

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, S (TC 1.A.1.2) subfamily, Kv9.1/KCNS1 sub-subfamily

Compartment

• cell membrane; multi-pass membrane protein
• may not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1

Expression

• expressed in most tissues
• not expressed skeletal muscle
• highly expressed in adult & fetal brain, fetal kidney & lung, & adult prostate & testis

More general terms

• transmembrane 6 protein
• calmodulin binding protein
• K+ channel subfamily S

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3787
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3787
• OMIM: https://mirror.omim.org/entry/602905
• UniProt: http://www.uniprot.org/uniprot/Q96KK3.html