RPE-retinal G protein-coupled receptor (RGR)

Function

• receptor for all-trans-retinal & 11-cis-retinal
• preferentially binds all-trans-retinal
• may catalyze the isomerization of the retinal by a retinochrome-like mechanism
• covalently binds all-trans-retinal & 11-cis-retinal

Structure

• belongs to the G-protein coupled receptor 1 family Opsin subfamily

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• preferentially expressed at high levels in the retinal pigment epithelium (RPE) & Mueller cells of the neural retina

Pathology

• defects in RGR are a cause of retinitis pigmentosa

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5995
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5995
• OMIM: https://mirror.omim.org/entry/268000
• OMIM: https://mirror.omim.org/entry/600342
• UniProt: http://www.uniprot.org/uniprot/P47804.html