ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A; sphingosylphosphorylcholine receptor (GPR68 OGR1)

Function

• proton-sensing receptor involved in pH homeostasis
• may represent an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone
• mediates its action by association with G proteins that stimulate inositol phosphate production or Ca+2 mobilization
• the receptor is almost silent at pH 7.8, but fully activated at pH 6.8
• function also as a metastasis suppressor gene in prostate cancer (putative)

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Expression

• found at low level in a wide range of tissues
• higher expression in lung, kidney, bone & nervous system

Notes

• originally thought to be a receptor for sphingosylphosphorylcholine; however, this work has been retracted

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8111
• OMIM: https://mirror.omim.org/entry/601404
• UniProt: http://www.uniprot.org/uniprot/Q15743.html