neuromedin-U receptor 1; NMU-R1; G-protein coupled receptor 66; G-protein coupled receptor FM-3 (NMUR1, GPR66)

Function

• receptor for the neuromedin-U & neuromedin-S neuropeptides (putative)

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Expression

• expressed in greatest abundance in peripheral organs, particularly in GI tract & urogenital systems
• highest expression in testes
• much lower expression in central nervous system
  • within the CNS, expressed in highest abundance in the cerebellum, dorsal root ganglia, hippocampus, & spinal cord

Notes

• uncertain whether Met-1 or Met-24 is the initiator

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Additional terms

• epididymis

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10316
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10316
• OMIM: https://mirror.omim.org/entry/604153
• UniProt: http://www.uniprot.org/uniprot/Q9HB89.html