free fatty acid receptor 2; G-protein coupled receptor 43 (FFAR2, GPR43)

Function

• receptor for short chain fatty acids
• actiivty mediated via Gi-protein inhibition of adenylyl cyclase & elevation of intracellular Ca+2
• the rank order affinity for free fatty acids is:
  • acetate= propionate = butyrate > pentanoate = formate

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Expression

• highly expressed in peripheral blood leukocytes
• lower expression in spleen

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2867
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2867
• OMIM: https://mirror.omim.org/entry/603823
• UniProt: http://www.uniprot.org/uniprot/O15552.html