free fatty acid receptor 1; G-protein coupled receptor 40 (FFAR1, GPR40)

Function

• receptor for medium & long chain saturated fatty acids & unsaturated fatty acids
• binding of ligand increases intracellular Ca+2 concentration & amplifys glucose-stimulated insulin secretion
• activity is mediated by G proteins that activate phospholipase C
• seems to act through a Gq & Gi-mediated pathway

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Expression

• abundantly expressed in pancreatic beta cells

Pharmacology

• TAK-875 is an experimental hypoglycemic agent for treatment of diabetes mellitus type 2 is an agonist of FFAR1

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2864
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2864
• OMIM: https://mirror.omim.org/entry/603820
• UniProt: http://www.uniprot.org/uniprot/O14842.html