G-protein coupled receptor family C group 6 member A (hGPRC6A, G-protein coupled receptor 33, hGPCR33, GPRC6A GPCR33)

Function

• activated by both amino acids & extracellular Ca+2
• linked to G-protein that activates IP3/Ca+2 second messenger system
• extracellular calcium-sensing in osteoblasts
• osteocalin, stimulates activity in presence of Ca+2
• lower affinity for calcium than CASR
• receptor for amino acids preference for basic amino acids L-Lys, L-Arg L-ornithine
• regulatory component of the urea cycle

Structure

homodimer, disulfide-linked, N-glycosylated

Compartment

cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=3

Expression

• expressed in brain, skeletal muscle, testis, bone, calvaria, osteoblasts, leukocytes > liver, heart, kidney, spleen > lung, pancreas, placenta, ovary.
• not expressed in thymus, prostate, small intestine, tongue, colon

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5T6X5.html