G-protein coupled receptor 33 (GPR33)

Function

• orphan receptor
• chemoattractant receptor (putative)

Expression

• expressed in spleen, lung, heart, liver, kidney, pancreas, thymus, gonads, leukocytes

Pathology

• GPR33 has undergone independent pseudogenization in human, chimpanzee, orangutan, siamang & rat
• selective inactivation may be due to its interaction with a putative pathogen that could use GPR33 as receptor for cell invasion

Polymorphism

• gene inactivated in most individuals
• in most individuals a nonsense mutation transforms Arg-140 into a premature stop codon.
• 1166 of 1217 individuals with a stop codon in both alleles, 50 heterozygous, 1 with Arg-140 in both alleles.

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/610118
• UniProt: http://www.uniprot.org/uniprot/Q49SQ1.html