oxoeicosanoid receptor 1 (G-protein coupled receptor TG1019, 5-oxo-ETE G-protein coupled receptor, G-protein coupled receptor 170, G-protein coupled receptor R527, OXER1, GPR170, TG1019)

Function

• receptor for eicosanoids & polyunsaturated fatty acids
  • 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE),
  • 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE)
  • arachidonic acid
• coupled to the Gi/Go heteromeric G proteins

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

membrane

Expression

• greatest in liver, kidney, peripheral leukocyte, lung, spleen
• not expressed in brain

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Additional terms

• 5-hydroperoxy-eicosatetraenoate
• arachidonate; arachidonic acid [C20:4w6, ARA]

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1651
• UniProt: http://www.uniprot.org/uniprot/Q8TDS5.html