stabilin 2; FEEL-2 protein; fasciclin EGF-like, laminin-type E-like & link domain-containing scavenger receptor 1; FAS1; EGF-like & X-link domain containing adhesion molecule 2; hyaluronan receptor for endocytosis (STAB2, FEEL2, FEL,L FEX2, HARE)

Function

• binds to & mediates endocytosis of hyaluronic acid (hyaluronan receptor)
• maintenance of tissue integrity by supporting extracellular matrix turnover
• maintenance of fluidity of body fluids by resorption of hyaluronan
• binds to both Gram-positive & Gram-negative bacteria
  • may play a role in defense against bacterial infection
• proteolytically processed to yield a 190 kD protein

Structure

• contains 17 EGF-like domains
• contains 7 FAS1 domains
• contains 2 laminin EGF-like domains
• contains 1 link domain

Compartment

plasma membrane

Expression

• expressed in sinusoidal endothelial cells of liver, spleen, lymph nodes

More general terms

• scavenger receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5557
• OMIM: https://mirror.omim.org/entry/608561
• UniProt: http://www.uniprot.org/uniprot/Q8WWQ8.html