stabilin 1 (FEEL-1 protein, MS-1 antigen, fasciclin EGF-like - laminin-type E-like & link domain-containing scavenger receptor 1, STAB1, FEEL1, KIAA0246)

Function

• acts as a scavenger receptor for acetylated low density lipoprotein
• binds to both Gram-positive & Gram-negative bacteria & may play a role in defense against bacterial infection
• when inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis
• role in delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system
• interacts with CHID1

Structure

• contains 16 EGF-like domains
• contains 7 FAS1 domains
• contains 2 laminin EGF-like domains
• contains 1 link domain

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• high levels found in spleen, lymph node, liver & placenta
• also expressed in endothelial cells

More general terms

• scavenger receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2316
• OMIM: https://mirror.omim.org/entry/608560
• UniProt: http://www.uniprot.org/uniprot/Q9NY15.html