scavenger receptor class F member 2 (scavenger receptor expressed by endothelial cells 2 protein, SREC-2, SRECRP-1)

Function

• probable adhesion protein
• mediates homophilic & heterophilic interactions via extracellular domain
• interacts with SCARF1
• interaction with SCARF1 stronger than the homophilic interaction with itself, is suppressed by the presence of SCARF1 ligand Ac-LDL
• in contrast to SCARF1, poorly mediates the binding & degradation of acetylated low density lipoprotein (Ac-LDL)

Structure

• homophilic & heterophilic interaction via its extracellular domain
• contains 7 EGF-like domains

Compartment

membrane

Expression

• predominantly expressed in endothelial cells
• expressed in heart, placenta, lung, kidney, spleen, small intestine & ovary

More general terms

• scavenger receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9117
• UniProt: http://www.uniprot.org/uniprot/Q96GP6.html