proteinase-activated receptor 4; PAR-4; thrombin receptor-like 3; coagulation factor II receptor-like 3 (F2RL3, PAR4)

Function

• receptor for activated thrombin or trypsin
• coupled to G proteins that stimulate phosphoinositide hydrolysis
• may play a role in platelets activation
• a proteolytic cleavage generates a new N-terminus that functions as a tethered ligand

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

• widely expressed
• highest levels in lung, pancreas, thyroid, testis & small intestine
• also detected in platelets
• not expressed in brain, kidney, spinal cord & peripheral blood leukocytes

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9002
• OMIM: https://mirror.omim.org/entry/602779
• UniProt: http://www.uniprot.org/uniprot/Q96RI0.html