melanocyte-stimulating hormone receptor; MSH-R; melanotropin receptor; melanocortin receptor 1; MC1-R (MC1R, MSHR)

Function

• receptor for MSH-alpha, MSH-beta & MSH-gamma & ACTH
• activity is mediated by G proteins which activate adenylate cyclase

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane

Expression

• expressed in melanocytes & corticoadrenal tissue

Polymorphism

• 15 MC1R variants
• variations in MC1R are linked to
  • skin pigmentation
  • skin/hair/eye pigmentation type 2 (SHEP2)
  • variations in photoaging

More general terms

• melanocortin receptor
• glycoprotein

Additional terms

• melanocyte-stimulating hormone (MSH)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4157
• OMIM: https://mirror.omim.org/entry/155555
• OMIM: https://mirror.omim.org/entry/266300
• UniProt: http://www.uniprot.org/uniprot/Q01726.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4157