melanocortin receptor 5; MC5-R; MC-2 (MC5R)

Function

• receptor for MSH-alpha, MSH-beta & MSH-gamma & ACTH
• activity is mediated by G proteins which activate adenylate cyclase
• possible mediator of the immunomodulation properties of melanocortins

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

expressed in the brain

Pathology

not expressed in melanoma cells

More general terms

• melanocortin receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4161
• OMIM: https://mirror.omim.org/entry/600042
• UniProt: http://www.uniprot.org/uniprot/P33032.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4161