solute carrier family 43 member 1 (large neutral amino acids transporter small subunit 3, L-type amino acid transporter 3, prostate cancer overexpressed gene 1 protein, SLC43A1, LAT3, PB39, POV1)

Function

• Na+ independent, high affinity transport of large neutral amino acids
• narrower substrate selectivity compared to SLC7A5 & SLC7A8
• mainly transports branched-chain amino acids & phenylalanine

Structure

• belongs to the SLC43A transporter (TC 2.A.1.44) family

Compartment

membrane (probable)

Alternative splicing

named isoforms=2

Expression

• in adults, found in all tissues examined
• highest expression in pancreas
• in fetus, highest expression in liver & lower levels in kidney, & lung

Pathology

• role in development of human prostate cancer
  • from prostatic intraepithelial neoplasia
  • to invasive prostate cancer
  • up-regulated in early prostate cancer development
• highest expression in seminomas of testicular germ cell tumors

More general terms

• solute carrier family 43 (SLC43, SLC43A)
• transmembrane 12 protein
• glycoprotein

Additional terms

• prostate cancer

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8501
• OMIM: https://mirror.omim.org/entry/603733
• UniProt: http://www.uniprot.org/uniprot/O75387.html