solute carrier family 10 member 2; ileal sodium/bile acid cotransporter; ileal Na+/bile acid cotransporter; Na+ dependent ileal bile acid transporter; ileal sodium-dependent bile acid transporter;ileal Na+/taurocholate cotransporting polypeptide (ISBT, ASBT, NTCP2, IBAT)

Function

• role in Na+ dependent reabsorption of bile acids from the lumen of the small intestine
• role in cholesterol metabolism

Structure

• monomer & homodimer
• belongs to the Na+:bile acid symporter family

Compartment

membrane

Pathology

• defects in SLC10A2 are a cause of primary bile acid malabsorption

Pharmacology

• odevixibat (Bylvay) is FDA-approved to treat pruritus in progressive familial intrahepatic cholestasis

More general terms

• solute carrier family 10 (SLC10, SLC10A)
• transmembrane 8e protein
• glycoprotein

Additional terms

• ileum

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6555
• OMIM: https://mirror.omim.org/entry/601295
• UniProt: http://www.uniprot.org/uniprot/Q12908.html