Thromboxane A2 receptor; TXA2-R; prostanoid TP receptor (TBXA2R)

Function

• receptor for thromboxane A2 (TXA2)
• stimulates platelet aggregation
• activityis mediated by a G-protein (Gq) that activates a phosphatidylinositol-Ca+2 second messenger system
• in the kidney, the binding of TXA2 to glomerular TBXA2R receptors causes intense vasoconstriction

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Alternative splicing

named isoforms=2

Pathology

• defects in TBXA2R are the cause of a dominantly inherited hereditary bleeding disorder

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein
• prostaglandin receptor

Additional terms

• thromboxane A

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6915
• OMIM: https://mirror.omim.org/entry/188070
• UniProt: http://www.uniprot.org/uniprot/P21731.html