insulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; prostacyclin-stimulating factor; tumor-derived adhesion factor; TAF (IGFBP7, MAC25, PSF)

Function

• binds IGF1 & IGF2 with low affinity
• stimulates prostacyclin (PGI2) production
• stimulates cell adhesion
• may interact with VPS24/CHMP

Structure

• N-glycosylated
• contains 1 Ig-like C2-type domain
• contains 1 IGFBP N-terminal domain
• contains 1 Kazal-like domain

Compartment

secreted

RNA editing

• modified_positions = 78, 95
• partially edited
• in the brain, position 78 is edited at about 55% & position 95 at about 31%

Pathology

• defects in IGFBP7 are the cause of RAMSVPS, retinal arterial macroaneurysm with supravalvular pulmonic stenosis

More general terms

• insulin-like growth factor [IGF]-binding protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3490
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3490
• OMIM: https://mirror.omim.org/entry/602867
• OMIM: https://mirror.omim.org/entry/614224
• UniProt: http://www.uniprot.org/uniprot/Q16270.html