insulin-like growth factor-binding protein 4; IBP-4; IGF-binding protein 4; IGFBP-4 (IGFBP4, IBP4)

Function

• IGF-binding proteins prolong the half-life of the IGFs
• they either inhibit or stimulate the growth promoting effects of the IGFs on cell culture
• they alter the interaction of IGFs with their cell surface receptors
• binds IGF2 more than IGF1

Structure

• contains 1 IGFBP N-terminal domain
• contains 1 thyroglobulin type-1 domain

Compartment

secreted

Expression

• induced by forskolin & N6,O2'dibutyryl adenosine 3',5'-cyclic monophosphate
• not induced by 1,9 dideoxyforskolin

More general terms

• insulin-like growth factor [IGF]-binding protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3487
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3487
• OMIM: https://mirror.omim.org/entry/146733
• UniProt: http://www.uniprot.org/uniprot/P22692.html