GDP-fucose protein O-fucosyltransferase 1; peptide-O-fucosyltransferase 1; O-fucT-1 (POFUT1, FUT12, KIAA0180)

Function

• attaches fucose through O-glycosidic linkage to conserved Ser or Thr in EGF domains
  • transfers an alpha-L-fucosyl residue from GDP-beta-L-fucose
• role in Notch signaling.

Cofactor: Mn+2

Structure

• N-glycosylated
• belongs to the glycosyltransferase 68 family

Compartment

endoplasmic reticulum

Alternative splicing

named isoforms=2

Expression

• expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas

More general terms

• fucosyltransferase
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23509
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23509
• OMIM: https://mirror.omim.org/entry/607491
• UniProt: http://www.uniprot.org/uniprot/Q9H488.html