transmembrane protease serine 11D; airway trypsin-like protease (TMPRSS11D, HAT)

Function

• role in host defense system on mucous membranes
• preferentially cleaves C-terminal side of arginine residues at the P1 position of certain peptides
• inhibited by diisopropyl fluorophosphate, leupeptin, antipain, aprotinin, soybean trypsin inhibitor

Kinetic parameters:

• optimum pH of 8.6

Structure

• monomer
• belongs to the peptidase S1 family
• contains 1 peptidase S1 domain
• contains 1 SEA domain

Compartment

• cell membrane, cleaved & secreted
• single-pass type 2 membrane

Expression

• expressed in cells of submucosal serous glands of bronchi & trachea

More general terms

• transmembrane serine protease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9407
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9407
• OMIM: https://mirror.omim.org/entry/605369
• UniProt: http://www.uniprot.org/uniprot/O60235.html