prenylcysteine oxidase 1; prenylcysteine lyase (PCYOX1, KIAA0908, PCL1, UNQ597/PRO1183)

Function

• role in degradation of prenylated proteins
• cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine & geranylgeranylcysteine

S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2

Cofactor: FAD

Structure

• glycosylated at one or more potential N-glycosylation sites
• belongs to the prenylcysteine oxidase family

Compartment

lysosome

Expression

ubiquitous

Notes

originally thought to be a lyase

More general terms

• oxidoreductase
• glycoprotein

Additional terms

• prenyl protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51449
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51449
• OMIM: https://mirror.omim.org/entry/610995
• UniProt: http://www.uniprot.org/uniprot/Q9UHG3.html