transmembrane protease serine 4; channel-activating protease 2; CAPH2; membrane-type serine protease 2; MT-SP2 (TMPRSS4, UNQ776/PRO1570)

Function

• probable protease
• seems to be capable of activating ENaC (putative)

Structure

• belongs to the peptidase S1 family
• contains 1 LDL-receptor class A domain
• contains 1 peptidase S1 domain
• contains 1 SRCR domain

Compartment

• membrane
• single-pass type 2 membrane protein (putative)

Alternative splicing

named isoforms=3

Expression

• high levels in pancreatic cancer, gastric cancer, colorectal carcinoma & ampullary cancer
• very weak expression in normal gastrointestinal tract & urogenital tract

More general terms

• transmembrane serine protease
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56649
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56649
• OMIM: https://mirror.omim.org/entry/606565
• UniProt: http://www.uniprot.org/uniprot/Q9NRS4.html