thyrotropin-releasing hormone-degrading ectoenzyme; TRH-DE; TRH-degrading ectoenzyme; EC=3.4.19.6; pyroglutamyl-peptidase II; PAP-II; TRH-specific aminopeptidase; thyroliberinase (TRHDE)

Function

• specific inactivation of TRH after its release
• release of the N-terminal pyroglutamyl group from pGlu-|-His-Xaa tripeptides & pGlu-|-His-Xaa-Gly tetrapeptides

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• homodimer; disulfide-linked (putative)
• belongs to the peptidase M1 family

Compartment

• membrane; single-pass type 2 membrane protein

Expression

predominantly expressed in brain

More general terms

• aminopeptidase
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29953
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29953
• OMIM: https://mirror.omim.org/entry/606950
• UniProt: http://www.uniprot.org/uniprot/Q9UKU6.html