angiopoietin-related protein 3; angiopoietin-like protein 3; angiopoietin-5; ANG-5 (ANGPTL3, ANGPT5, UNQ153/PRO179)

Function

• ANGPTL3 inhibits lipoprotein lipase & endothelial lipase

Structure

• contains 1 fibrinogen C-terminal domain

Compartment

secreted (putative)

Expression

• expressed predominantly in liver
• weakly expressed in kidney

Pharmacology

• evinacumab-dgnb (Evkeeza) is a recombinant monoclonal Ab that binds to & inhibits angiopoietin-like 3 (ANGPTL3) FDA-approved for treatment of homozygous familial hypercholesterolemia

More general terms

• angiopoietin like
• angiopoietin
• glycoprotein
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27329
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27329
• OMIM: https://mirror.omim.org/entry/604774
• UniProt: http://www.uniprot.org/uniprot/Q9Y5C1.html