Na+ channel protein type 6 subunit alpha; Na+ channel protein type 7 subunit alpha; voltage-gated Na+ channel subunit alpha Nax; Na+ channel protein cardiac & skeletal muscle subunit alpha (SCN7A, SCN6A)

Function

• mediates voltage-dependent Na+ permeability of excitable membranes
• assumes opened or closed conformation in response to voltage difference across the membrane
• forms a Na+-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient

Structure

• 24 transmembrane domains
• contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) & one positively charged segment (S4)
• segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every 3rd position
• belongs to the Na+ channel family

Compartment

membrane

Expression

heart & uterus

More general terms

• voltage-dependent Na+ channel protein alpha subunit
• glycoprotein
• phosphoprotein

Additional terms

• voltage-dependent Na+ channel

Database

• UniProt: http://www.uniprot.org/uniprot/Q01118.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6332
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6332
• OMIM: https://mirror.omim.org/entry/182392