renal dipeptidase; microsomal dipeptidase; dipeptidase 1 (DPEP1, MDP, RDP)

Function

• hydrolyzes a wide range of dipeptides
• implicated in renal metabolism of glutathione & its conjugates
• converts leukotriene D4 to leukotriene E4
• may play role in regulation of leukotriene activity
• inhibited by L-penicillamine (putative)
• hydrolysis of dipeptides

Cofactor: Zn+2

Structure

• homodimer, disulfide-linked
• belongs to the peptidase M19 family

Compartment

• apical cell membrane, lipid-anchor, GPI-anchor
• cell projection, microvillus membrane
• brush border membrane

More general terms

• dipeptidase
• glypiated protein
• oligomerizing protein
• glycoprotein
• metalloprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P16444.html
• OMIM: https://mirror.omim.org/entry/179780
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1800