receptor-type tyrosine-protein phosphatase kappa; protein-tyrosine phosphatase kappa; R-PTP-kappa (PTPRK, PTPK)

Function

• regulation of processes involving cell contact & adhesion such as growth control, tumor invasion, & metastasis
• forms complexes with beta-catenin & gamma-catenin/plakoglobin
• beta-catenin may be a substrate for the catalytic activity of PTP- kappa
• undergoes proteolytic processing

protein tyrosine phosphate + H2O = protein tyrosine + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family receptor class 2B subfamily
• contains 4 fibronectin F3 modules
• contains 1 Ig-like C2-type domain
• contains 1 MAM domain
• contains 2 tyrosine-protein phosphatase domains

Compartment

• cell junction, adherens junction
• cell membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2

Expression

• high levels in lung, brain & colon
• less expression in liver, pancreas, stomach, kidney, placenta & mammary carcinoma

More general terms

• tyrosine phosphatase, receptor type
• plasma membrane protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5796
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5796
• OMIM: https://mirror.omim.org/entry/602545
• UniProt: http://www.uniprot.org/uniprot/Q15262.html