N-acetylgalactosamine-6-sulfatase; galactose-6-sulfatase; chondroitin sulfatase; chondroitinase (GALNS)
Jump to navigation
Jump to search
Function
- hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate & of the D-galactose 6-sulfate units of keratan sulfate
Cofactor: binds 1 Ca+2 per subunit (putative)
Structure
belongs to the sulfatase family
Compartment
Pathology
- deficient in Morquio's disease type A (mucopolysaccharidosis-IVa)
More general terms
References
- ↑ Textbook of Biochemistry with Clinical Correlations, 3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 383
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=GALNS
- ↑ UniProt http://www.uniprot.org/uniprot/P34059.html