proprotein convertase PC5 (proprotein convertase subtilisin/kexin type 5, subtilisin/kexin-like protease PC5, prohormone convertase PC5, PC6, hPC6)

Function

• widespread endoprotease activity within constitutive & regulated secretory pathway (putative)
• capable of cleavage at the RX(K/R)R consensus motif
• release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid & Yaa is Arg or Lys

Structure

• propeptide domain acts as an intramolecular chaperone assisting folding of zymogen within the endoplasmic reticulum
• belongs to the peptidase S8 family
• contains 1 homo B/P domain
• contains 1 PLAC domain

Compartment

secreted (putative)

Alternative splicing

named isoforms=1

2 isoforms may be produced

Expression

expressed in T-lymphocytes

More general terms

• subtilase
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/600488
• UniProt: http://www.uniprot.org/uniprot/Q92824.html